|Title||Rigid orthogonal bis-TEMPO biradicals with improved solubility for dynamic nuclear polarization.|
|Publication Type||Journal Article|
|Year of Publication||2012|
|Authors||Dane, EL, Corzilius, B\örn, Rizzato, E, Stocker, P, Maly, T, Smith, AA, Griffin, RG, Ouari, O, Tordo, P, Swager, TM|
|Journal||The Journal of organic chemistry|
|Keywords||Cyclic N-Oxides, Cyclic N-Oxides: chemical synthesis, Magnetic Resonance Spectroscopy, Magnetic Resonance Spectroscopy: methods, Oxidation-Reduction, Solubility, Spin Labels, Spin Labels: chemical synthesis, Sulfoxides, Sulfoxides: chemistry, Sulfur, Sulfur: chemistry, Water|
The synthesis and characterization of oxidized bis-thioketal-trispiro dinitroxide biradicals that orient the nitroxides in a rigid, approximately orthogonal geometry are reported. The biradicals show better performance as polarizing agents in dynamic nuclear polarization (DNP) NMR experiments as compared to biradicals lacking the constrained geometry. In addition, the biradicals display improved solubility in aqueous media due to the presence of polar sulfoxides. The results suggest that the orientation of the radicals is not dramatically affected by the oxidation state of the sulfur atoms in the biradical, and we conclude that a biradical polarizing agent containing a mixture of oxidation states can be used for improved solubility without a loss in performance.