|Title||Anthryl-doped conjugated polyelectrolytes as aggregation-based sensors for nonquenching multicationic analytes.|
|Publication Type||Journal Article|
|Year of Publication||2007|
|Authors||Satrijo, A, Swager, TM|
|Journal||Journal of the American Chemical Society|
|Keywords||Cations, Electrolytes, Electrolytes: chemistry, Fluorescence, Spectrometry, Static Electricity|
The fluorescence-based detection of nonquenching, multicationic small molecules has been demonstrated using a blue-emitting, polyanionic poly(p-phenylene ethynylene) (PPE) doped with green-emitting exciton traps (anthryl units). Multicationic amines (spermine, spermidine, and neomycin) were found to effectively induce the formation of tightly associated aggregates between the polymer chains in solution. This analyte-induced aggregation, which was accompanied by enhanced exciton migration in the PPE, ultimately led to a visually noticeable blue-to-green fluorescence color change in the solution. The aggregation-based sensor exhibited poor sensitivity toward dicationic and monocationic amines, demonstrating that a conjugated polyelectrolyte sensor relying on nonspecific, electrostatic interactions may still attain a certain level of selectivity.