Fluorescent detection of chemical warfare agents: functional group specific ratiometric chemosensors.
Title
Fluorescent detection of chemical warfare agents: functional group specific ratiometric chemosensors.
Publication Type
Journal Article
Year of Publication
2003
Authors
Journal
Journal of the American Chemical Society
Volume
125
Pagination
3420–1
Date Published
mar
ISSN
0002-7863
Keywords
Chemical Warfare Agents, Chemical Warfare Agents: analysis, Fluorescence, Fluorescence: methods, Fluorescent Dyes, Fluorescent Dyes: chemistry, Indicators and Reagents, Indicators and Reagents: chemistry, Organophosphorus Compounds, Organophosphorus Compounds: analysis, Pyridines, Pyridines: chemistry, Spectrometry
Abstract
Indicators providing highly sensitive and functional group specific fluorescent response to diisopropyl fluorophosphate (DFP, a nerve gas (G-agent) simulant) are reported. Nonemissive indicator 2 reacts with DFP to give a cyclized compound 2+A- that shows a high emission due to its highly planar and rigid structure. Very weak emission was observed by the addition of HCl. Another indicator based on pyridyl naphthalene exhibits a large shift in its emission spectrum after reaction with DFP, which provides for quantitative ratiometric detection.