Smart optical probes for near-infrared fluorescence imaging of Alzheimer’s disease pathology.

Title

Smart optical probes for near-infrared fluorescence imaging of Alzheimer’s disease pathology.

Publication Type

Journal Article

Year of Publication

2008

Authors

Journal

European journal of nuclear medicine and molecular imaging

Volume

35 Suppl 1

Pagination

S93–8

Date Published

mar

ISSN

1619-7070

Keywords

Alzheimer Disease, Alzheimer Disease: pathology, Animals, Brain, Brain: pathology, Fluorescence, Fluorescence: methods, Fluorescent Dyes, Fluorescent Dyes: diagnostic use, Humans, Microscopy, Molecular Probe Techniques, Near-Infrared, Near-Infrared: methods, Spectroscopy

Abstract

Near-infrared fluorescent probes for amyloid-beta (Abeta) are an exciting option for molecular imaging in Alzheimer’s disease research and may translate to clinical diagnostics. However, Abeta-targeted optical probes often suffer from poor specificity and slow clearance from the brain. We are designing smart optical probes that emit characteristic fluorescence signal only when bound to Abeta.

URL

http://www.ncbi.nlm.nih.gov/pubmed/18236039

DOI

http://dx.doi.org/10.1007/s00259-007-0708-7

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DOI