Dynamic nuclear polarization with a water-soluble rigid biradical.

TitleDynamic nuclear polarization with a water-soluble rigid biradical.
Publication TypeJournal Article
Year of Publication2012
AuthorsKiesewetter, MK, Corzilius, B\örn, Smith, AA, Griffin, RG, Swager, TM
JournalJournal of the American Chemical Society
Date Publishedmar
KeywordsCrystallography, Electron Spin Resonance Spectroscopy, Magnetic Resonance Spectroscopy, Solubility, Water, Water: chemistry, X-Ray

A new biradical polarizing agent, bTbtk-py, for dynamic nuclear polarization (DNP) experiments in aqueous media is reported. The synthesis is discussed in light of the requirements of the optimum, theoretical, biradical system. To date, the DNP NMR signal enhancement resulting from bTbtk-py is the largest of any biradical in the ideal glycerol/water solvent matrix, $ε$ = 230. EPR and X-ray crystallography are used to characterize the molecule and suggest approaches for further optimizing the biradical distance and relative orientation.