MIT

A Highly Selective Fluorescent Probe for Thiol Bioimaging.

Title

A Highly Selective Fluorescent Probe for Thiol Bioimaging.

Publication Type
Journal Article
Year of Publication
2008
Journal
Organic Letters
Volume
10
Pagination
37–40
ISSN
1523-7060
Abstract
A new fluorescent turn-on probe (I) for the selective sensing and bioimaging of thiols is reported. In aq. buffer solns. at physiol. pH, thiols cleave the 2,4-dinitrobenzenesulfonyl group to release the red-emissive donor-acceptor fluorophore. The probe displays excellent immunity to interference from nitrogen and oxygen nucleophiles and the imaging of thiols in living cells is demonstrated. [on SciFinder(R)]