Title | Simultaneous Identification of Neutral and Anionic Species in Complex Mixtures without Separation |
Publication Type | Journal Article |
Year of Publication | 2015 |
Authors | Zhao, Y, Chen, L, Swager, TM |
Journal | Angewandte Chemie, International Edition |
Pagination | Ahead of Print |
ISSN | 1433-7851 |
Keywords | caffeine neutral anionic coffee tea energy beverage fluorine NMR |
Abstract | A chemosensory system is reported that operates without the need for sepn. techniques and is capable of identifying anions and structurally similar bioactive mols. In this strategy, the coordination of analytes to a metal complex with an open binding cleft generates \"static structures\" on the NMR timescale. Unique signals are created by strategically placing fluorine atoms in close proximity to bound analytes so that small structural differences induce distinct 19F NMR shifts that can be used to identify each analyte. The utility of this method is illustrated by quantifying caffeine levels in coffee, by identifying ingredients in tea and energy drinks, and by discriminating between multiple biogenic amines with remote structural differences six carbon atoms away from the binding site. We further demonstrate the simultaneous identification of multiple neutral and anionic species in a complex mixture |
DOI | 10.1002/anie.201508085 |