In vivo optical imaging of amyloid aggregates in brain: design of fluorescent markers.
Title
In vivo optical imaging of amyloid aggregates in brain: design of fluorescent markers.
Publication Type
Journal Article
Year of Publication
2005
Journal
Angewandte Chemie, International Edition
Volume
44
Pagination
5452–6
Date Published
aug
ISSN
1433-7851
Keywords
Alzheimer Disease, Alzheimer Disease: diagnosis, Amyloid, Amyloid: chemistry, Amyloid: metabolism, Animals, Brain, Brain: metabolism, Diagnostic Imaging, Diagnostic Imaging: methods, Fluorescence, Fluorescent Dyes, Fluorescent Dyes: chemical synthesis, Fluorescent Dyes: chemistry, Fluorescent Dyes: pharmacokinetics, Mice, Molecular Structure, Nitriles, Nitriles: chemical synthesis, Nitriles: chemistry, Nitriles: pharmacokinetics, Spectrometry, Thiophenes, Thiophenes: chemical synthesis, Thiophenes: chemistry, Thiophenes: pharmacokinetics
Abstract
Routine diagnostics and studies of Alzheimer’s disease might benefit form the noninvasive optical imaging of amyloid-$beta$ plaques in the brain. A rational design strategy for in vivo amyloid-imaging agents that enter the brain and selectively stain amyloid plaques is presented (see picture), and properties of a promising lead biomarker candidate are reported. [on SciFinder(R)]