| Title | Fluorescent detection of chemical warfare agents: functional group specific ratiometric chemosensors. |
| Publication Type | Journal Article |
| Year of Publication | 2003 |
| Authors | Zhang, S-W, Swager, TM |
| Journal | Journal of the American Chemical Society |
| Volume | 125 |
| Pagination | 3420–1 |
| Date Published | mar |
| ISSN | 0002-7863 |
| Keywords | Chemical Warfare Agents, Chemical Warfare Agents: analysis, Fluorescence, Fluorescence: methods, Fluorescent Dyes, Fluorescent Dyes: chemistry, Indicators and Reagents, Indicators and Reagents: chemistry, Organophosphorus Compounds, Organophosphorus Compounds: analysis, Pyridines, Pyridines: chemistry, Spectrometry |
| Abstract | Indicators providing highly sensitive and functional group specific fluorescent response to diisopropyl fluorophosphate (DFP, a nerve gas (G-agent) simulant) are reported. Nonemissive indicator 2 reacts with DFP to give a cyclized compound 2+A- that shows a high emission due to its highly planar and rigid structure. Very weak emission was observed by the addition of HCl. Another indicator based on pyridyl naphthalene exhibits a large shift in its emission spectrum after reaction with DFP, which provides for quantitative ratiometric detection. |
| URL | http://www.ncbi.nlm.nih.gov/pubmed/12643690 |
| DOI | 10.1021/ja029265z |