|Title||Smart optical probes for near-infrared fluorescence imaging of Alzheimer's disease pathology.|
|Publication Type||Journal Article|
|Year of Publication||2008|
|Authors||Raymond, SB, Skoch, J, Hills, ID, Nesterov, EE, Swager, TM, Bacskai, BJ|
|Journal||European journal of nuclear medicine and molecular imaging|
|Volume||35 Suppl 1|
|Keywords||Alzheimer Disease, Alzheimer Disease: pathology, Animals, Brain, Brain: pathology, Fluorescence, Fluorescence: methods, Fluorescent Dyes, Fluorescent Dyes: diagnostic use, Humans, Microscopy, Molecular Probe Techniques, Near-Infrared, Near-Infrared: methods, Spectroscopy|
Near-infrared fluorescent probes for amyloid-beta (Abeta) are an exciting option for molecular imaging in Alzheimer's disease research and may translate to clinical diagnostics. However, Abeta-targeted optical probes often suffer from poor specificity and slow clearance from the brain. We are designing smart optical probes that emit characteristic fluorescence signal only when bound to Abeta.