Title | Smart optical probes for near-infrared fluorescence imaging of Alzheimer's disease pathology. |
Publication Type | Journal Article |
Year of Publication | 2008 |
Authors | Raymond, SB, Skoch, J, Hills, ID, Nesterov, EE, Swager, TM, Bacskai, BJ |
Journal | European journal of nuclear medicine and molecular imaging |
Volume | 35 Suppl 1 |
Pagination | S93–8 |
Date Published | mar |
ISSN | 1619-7070 |
Keywords | Alzheimer Disease, Alzheimer Disease: pathology, Animals, Brain, Brain: pathology, Fluorescence, Fluorescence: methods, Fluorescent Dyes, Fluorescent Dyes: diagnostic use, Humans, Microscopy, Molecular Probe Techniques, Near-Infrared, Near-Infrared: methods, Spectroscopy |
Abstract | Near-infrared fluorescent probes for amyloid-beta (Abeta) are an exciting option for molecular imaging in Alzheimer's disease research and may translate to clinical diagnostics. However, Abeta-targeted optical probes often suffer from poor specificity and slow clearance from the brain. We are designing smart optical probes that emit characteristic fluorescence signal only when bound to Abeta. |
URL | http://www.ncbi.nlm.nih.gov/pubmed/18236039 |
DOI | 10.1007/s00259-007-0708-7 |