| Title | In vivo optical imaging of amyloid aggregates in brain: design of fluorescent markers. |
| Publication Type | Journal Article |
| Year of Publication | 2005 |
| Authors | Nesterov, EE, Skoch, J, Hyman, BT, Klunk, WE, Bacskai, BJ, Swager, TM |
| Journal | Angewandte Chemie, International Edition |
| Volume | 44 |
| Pagination | 5452–6 |
| Date Published | aug |
| ISSN | 1433-7851 |
| Keywords | Alzheimer Disease, Alzheimer Disease: diagnosis, Amyloid, Amyloid: chemistry, Amyloid: metabolism, Animals, Brain, Brain: metabolism, Diagnostic Imaging, Diagnostic Imaging: methods, Fluorescence, Fluorescent Dyes, Fluorescent Dyes: chemical synthesis, Fluorescent Dyes: chemistry, Fluorescent Dyes: pharmacokinetics, Mice, Molecular Structure, Nitriles, Nitriles: chemical synthesis, Nitriles: chemistry, Nitriles: pharmacokinetics, Spectrometry, Thiophenes, Thiophenes: chemical synthesis, Thiophenes: chemistry, Thiophenes: pharmacokinetics |
| Abstract | Routine diagnostics and studies of Alzheimer's disease might benefit form the noninvasive optical imaging of amyloid-$\beta$ plaques in the brain. A rational design strategy for in vivo amyloid-imaging agents that enter the brain and selectively stain amyloid plaques is presented (see picture), and properties of a promising lead biomarker candidate are reported. [on SciFinder(R)] |
| URL | http://www.ncbi.nlm.nih.gov/pubmed/16059955 |
| DOI | 10.1002/anie.200500845 |